Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC4064348 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Zhou Yan Y Sun Kai K Ma Yi Y Yang Haozheng H Zhang Yuanliang Y Kong Xianming X Wei Lixin L
Scientific reports 20140620
The tumor microenvironment, including ischemia, has been increasingly recognized as a critical factor in the process of tumor development. Hypoxia and nutrient deficiency resulting from ischemia widely exist in solid tumors. Recent studies have shown that hypoxia and nutrient deficiency contribute to chemoresistance by inducing autophagy, but the underlying mechanism remains unknown. This study aimed to explore the role of autophagy induced by low glucose and hypoxia (LH) in the chemoresistance ...[more]