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Inducing sleep by remote control facilitates memory consolidation in Drosophila.

ABSTRACT: Sleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel Transient receptor potential cation channel (UAS-TrpA1) in neurons, including those with projections to the dorsal fan-shaped body (FB). When the temperature was raised to 31°C, flies entered a quiescent state that meets the criteria for identifying sleep. When sleep was induced for 4 hours after a massed-training protocol for courtship conditioning that is not capable of inducing long-term memory (LTM) by itself, flies develop an LTM. Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training.

SUBMITTER: Donlea JM

PROVIDER: S-EPMC4064462 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Inducing sleep by remote control facilitates memory consolidation in Drosophila.

Donlea Jeffrey M JM Thimgan Matthew S MS Suzuki Yasuko Y Gottschalk Laura L Shaw Paul J PJ

Science (New York, N.Y.) 20110601 6037

Sleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel Transient receptor potential cation channel (UAS-TrpA1) in neurons, including those with projections to the dorsal fan-shaped body (FB). When the temperature was raised to 31°C, flies entered a quiescent state that meets the criteria for identifying sleep. When sleep was induced for 4 hours after a massed-training protocol for courtship co ...[more]

PMID: 21700877

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