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A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro.

ABSTRACT: Basic cellular and network mechanisms underlying gamma frequency oscillations (30-80 Hz) have been well characterized in the hippocampus and associated structures. In these regions, gamma rhythms are seen as an emergent property of networks of principal cells and fast-spiking interneurons. In contrast, in the neocortex a number of elegant studies have shown that specific types of principal neuron exist that are capable of generating powerful gamma frequency outputs on the basis of their intrinsic conductances alone. These fast rhythmic bursting (FRB) neurons (sometimes referred to as "chattering" cells) are activated by sensory stimuli and generate multiple action potentials per gamma period. Here, we demonstrate that FRB neurons may function by providing a large-scale input to an axon plexus consisting of gap-junctionally connected axons from both FRB neurons and their anatomically similar counterparts regular spiking neurons. The resulting network gamma oscillation shares all of the properties of gamma oscillations generated in the hippocampus but with the additional critical dependence on multiple spiking in FRB cells.

SUBMITTER: Cunningham MO

PROVIDER: S-EPMC406481 | biostudies-literature | 2004 May

REPOSITORIES: biostudies-literature

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A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro.

Cunningham Mark O MO Whittington Miles A MA Bibbig Andrea A Roopun Anita A LeBeau Fiona E N FE Vogt Angelika A Monyer Hannah H Buhl Eberhard H EH Traub Roger D RD

Proceedings of the National Academy of Sciences of the United States of America 20040421 18

Basic cellular and network mechanisms underlying gamma frequency oscillations (30-80 Hz) have been well characterized in the hippocampus and associated structures. In these regions, gamma rhythms are seen as an emergent property of networks of principal cells and fast-spiking interneurons. In contrast, in the neocortex a number of elegant studies have shown that specific types of principal neuron exist that are capable of generating powerful gamma frequency outputs on the basis of their intrinsi ...[more]

PMID: 15103017

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Project description:Humans can rapidly detect regular patterns (i.e., within few cycles) without any special attention to the acoustic environment. This suggests that human sensory systems are equipped with a powerful mechanism for automatically predicting forthcoming stimuli to detect regularity. It has recently been hypothesized that the neural basis of sensory predictions exists for not only what happens (predictive coding) but also when a particular stimulus occurs (predictive timing). Here, we hypothesize that the phases of neural oscillations are critical in predictive timing, and these oscillations are modulated in a band-specific manner when acoustic patterns become predictable, i.e., regular. A high-density microelectrode array (10 × 10 within 4 × 4 mm2) was used to characterize spatial patterns of band-specific oscillations when a random-tone sequence was switched to a regular-tone sequence. Increasing the regularity of the tone sequence enhanced phase locking in a band-specific manner, notwithstanding the type of the regular sound pattern. Gamma-band phase locking increased immediately after the transition from random to regular sequences, while beta-band phase locking gradually evolved with time after the transition. The amplitude of the tone-evoked response, in contrast, increased with frequency separation with respect to the prior tone, suggesting that the evoked-response amplitude encodes sequence information on a local scale, i.e., the local order of tones. The phase locking modulation spread widely over the auditory cortex, while the amplitude modulation was confined around the activation foci. Thus, our data suggest that oscillatory phase plays a more important role than amplitude in the neuronal detection of tone sequence regularity, which is closely related to predictive timing. Furthermore, band-specific contributions may support recent theories that gamma oscillations encode bottom-up prediction errors, whereas beta oscillations are involved in top-down prediction.

Dataset Information

A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro.

Publications

A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro.

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