Ontology highlight
ABSTRACT:
SUBMITTER: Wojcik SM
PROVIDER: S-EPMC406482 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Wojcik S M SM Rhee J S JS Herzog E E Sigler A A Jahn R R Takamori S S Brose N N Rosenmund C C
Proceedings of the National Academy of Sciences of the United States of America 20040421 18
Quantal neurotransmitter release at excitatory synapses depends on glutamate import into synaptic vesicles by vesicular glutamate transporters (VGLUTs). Of the three known transporters, VGLUT1 and VGLUT2 are expressed prominently in the adult brain, but during the first two weeks of postnatal development, VGLUT2 expression predominates. Targeted deletion of VGLUT1 in mice causes lethality in the third postnatal week. Glutamatergic neurotransmission is drastically reduced in neurons from VGLUT1-d ...[more]