Ontology highlight
ABSTRACT:
SUBMITTER: Allen PB
PROVIDER: S-EPMC406487 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Allen Patrick B PB Greenfield Audrey T AT Svenningsson Per P Haspeslagh Derek C DC Greengard Paul P
Proceedings of the National Academy of Sciences of the United States of America 20040423 18
Protein phosphatase 1 (PP1) is a multifunctional enzyme with diverse roles in the nervous system, including regulation of synaptic activity and dendritic morphology. PP1 activity is controlled via association with a family of regulatory subunits that govern subcellular localization and substrate specificity. A previously undescribed class of PP1-binding proteins was detected by interaction cloning. Family members were also found to bind to cytoplasmic actin via Arg, Pro, Glu, and Leu repeat-cont ...[more]