Ontology highlight
ABSTRACT:
SUBMITTER: Yoshizaki K
PROVIDER: S-EPMC4065011 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
PloS one 20140620 6
Cell fates are determined by specific transcriptional programs. Here we provide evidence that the transcriptional coactivator, Mediator 1 (Med1), is essential for the cell fate determination of ectodermal epithelia. Conditional deletion of Med1 in vivo converted dental epithelia into epidermal epithelia, causing defects in enamel organ development while promoting hair formation in the incisors. We identified multiple processes by which hairs are generated in Med1 deficient incisors: 1) dental ep ...[more]