Dataset Information

Aspirin intake and breast cancer survival - a nation-wide study using prospectively recorded data in Sweden.

ABSTRACT:

Background

Aspirin (ASA) use has been associated with improved breast cancer survival in several prospective studies.

Methods

We conducted a nested case-control study of ASA use after a breast cancer diagnosis among women using Swedish National Registries. We assessed prospectively recorded ASA exposure during several different time windows following cancer diagnosis using conditional logistic regression with breast cancer death as the main outcome. Within each six-month period of follow-up, we categorized dispensed ASA doses into three groups: 0, less than 1, and 1 or more daily doses.

Results

We included 27,426 women diagnosed with breast cancer between 2005 and 2009; 1,661 died of breast cancer when followed until Dec 31, 2010. There was no association between ASA use and breast cancer death when exposure was assessed either shortly after diagnosis, or 3-12 months before the end of follow-up. Only during the period 0-6 months before the end of follow-up was ASA use at least daily compared with non-use associated with a decreased risk of breast cancer death: HR (95% CI)?=0.69 (0.56-0.86). However, in the same time-frame, those using ASA less than daily had an increased risk of breast cancer death: HR (95% CI)?=1.43 (1.09-1.87).

Conclusions

Contrary to other studies, we did not find that ASA use was associated with a lower risk of death from breast cancer, except when assessed short term with no delay to death/end of follow-up, which may reflect discontinuation of ASA during terminal illness.

SUBMITTER: Holmes MD

PROVIDER: S-EPMC4065077 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Publications

Aspirin intake and breast cancer survival - a nation-wide study using prospectively recorded data in Sweden.

Holmes Michelle D MD Olsson Henrik H Pawitan Yudi Y Holm Johanna J Lundholm Cecilia C Andersson Therese M-L TM Adami Hans-Olov HO Askling Johan J Smedby Karin Ekström KE

BMC cancer 20140602

<h4>Background</h4>Aspirin (ASA) use has been associated with improved breast cancer survival in several prospective studies.<h4>Methods</h4>We conducted a nested case-control study of ASA use after a breast cancer diagnosis among women using Swedish National Registries. We assessed prospectively recorded ASA exposure during several different time windows following cancer diagnosis using conditional logistic regression with breast cancer death as the main outcome. Within each six-month period of ...[more]

PMID: 24890520

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Dataset Information

Aspirin intake and breast cancer survival - a nation-wide study using prospectively recorded data in Sweden.

Background

Methods

Results

Conclusions

Publications

Aspirin intake and breast cancer survival - a nation-wide study using prospectively recorded data in Sweden.

Similar Datasets

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