PTPRT regulates high-fat diet-induced obesity and insulin resistance.
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ABSTRACT:
SUBMITTER: Feng X
PROVIDER: S-EPMC4065109 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
PTPRT regulates high-fat diet-induced obesity and insulin resistance.
Feng Xiujing X Scott Anthony A Wang Yong Y Wang Lan L Zhao Yiqing Y Doerner Stephanie S Satake Masanobu M Croniger Colleen M CM Wang Zhenghe Z
PloS one 20140620 6
Obesity is a risk factor for many human diseases. However, the underlying molecular causes of obesity are not well understood. Here, we report that protein tyrosine phosphatase receptor T (PTPRT) knockout mice are resistant to high-fat diet-induced obesity. Those mice avoid many deleterious side effects of high-fat diet-induced obesity, displaying improved peripheral insulin sensitivity, lower blood glucose and insulin levels. Compared to wild type littermates, PTPRT knockout mice show reduced f ...[more]
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