Ontology highlight
ABSTRACT:
SUBMITTER: Selvaraj S
PROVIDER: S-EPMC4065195 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Selvaraj S S Ghebremichael M M Li M M Foli Y Y Langs-Barlow A A Ogbuagu A A Barakat L L Tubridy E E Edifor R R Lam W W Cheng Y-C YC Paintsil E E
Clinical pharmacology and therapeutics 20140317 1
We hypothesized that competition between nucleotide reverse-transcriptase inhibitor triphosphate and endogenous deoxyribonucleotide triphosphate (dNTP) may lead to depletion of dNTP pools and mitochondrial dysfunction independent of polymerase-γ (pol-γ) inhibition. We collected peripheral blood mononuclear cells from 75 adults (25 cases: HIV-infected patients with mitochondrial toxicity, 25 HIV-infected positive controls, and 25 HIV-negative controls). We observed statistically significant indiv ...[more]