Ontology highlight
ABSTRACT:
SUBMITTER: Iglesias A
PROVIDER: S-EPMC406522 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Iglesias Ainhoa A Murga Matilde M Laresgoiti Usua U Skoudy Anouchka A Bernales Irantzu I Fullaondo Asier A Moreno Bernardino B Lloreta José J Field Seth J SJ Real Francisco X FX Zubiaga Ana M AM
The Journal of clinical investigation 20040501 10
E2F transcription factors are thought to be key regulators of cell growth control. Here we use mutant mouse strains to investigate the function of E2F1 and E2F2 in vivo. E2F1/E2F2 compound-mutant mice develop nonautoimmune insulin-deficient diabetes and exocrine pancreatic dysfunction characterized by endocrine and exocrine cell dysplasia, a reduction in the number and size of acini and islets, and their replacement by ductal structures and adipose tissue. Mutant pancreatic cells exhibit increas ...[more]