Ontology highlight
ABSTRACT:
SUBMITTER: Taketomi Y
PROVIDER: S-EPMC4065307 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Taketomi Yoshitaka Y Ueno Noriko N Kojima Takumi T Sato Hiroyasu H Murase Remi R Yamamoto Kei K Tanaka Satoshi S Sakanaka Mariko M Nakamura Masanori M Nishito Yasumasa Y Kawana Momoko M Kambe Naotomo N Ikeda Kazutaka K Taguchi Ryo R Nakamizo Satoshi S Kabashima Kenji K Gelb Michael H MH Arita Makoto M Yokomizo Takehiko T Nakamura Motonao M Watanabe Kikuko K Hirai Hiroyuki H Nakamura Masataka M Okayama Yoshimichi Y Ra Chisei C Aritake Kosuke K Urade Yoshihiro Y Morimoto Kazushi K Sugimoto Yukihiko Y Shimizu Takao T Narumiya Shuh S Hara Shuntaro S Murakami Makoto M
Nature immunology 20130428 6
Microenvironment-based alterations in phenotypes of mast cells influence the susceptibility to anaphylaxis, yet the mechanisms underlying proper maturation of mast cells toward an anaphylaxis-sensitive phenotype are incompletely understood. Here we report that PLA2G3, a mammalian homolog of anaphylactic bee venom phospholipase A2, regulates this process. PLA2G3 secreted from mast cells is coupled with fibroblastic lipocalin-type PGD2 synthase (L-PGDS) to provide PGD2, which facilitates mast-cell ...[more]