Ontology highlight
ABSTRACT:
SUBMITTER: Quinn M
PROVIDER: S-EPMC4065628 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Quinn Matthew M McMillin Matthew M Galindo Cheryl C Frampton Gabriel G Pae Hae Yong HY DeMorrow Sharon S
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20140312 6
<h4>Background</h4>The blood brain barrier tightly regulates the passage of molecules into the brain and becomes leaky following obstructive cholestasis. The aim of this study was to determine if increased serum bile acids observed during cholestasis permeabilize the blood brain barrier.<h4>Methods</h4>Rats underwent bile duct ligation or deoxycholic or chenodeoxycholic acid injections and blood brain barrier permeability assessed. In vitro, the permeability of rat brain microvessel endothelial ...[more]