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MicroRNAs in autoimmune diseases.


ABSTRACT: Autoimmune diseases (ADs) are featured by body's immune responses being directed towards its own specific target organs or multiple organ systems, causing persistent inflammation and consequent tissue damage. miRNAs are small noncoding RNAs in a size of approximately 22?nt that play important regulatory roles in many organisms by cleavage or translational inhibition of targeted mRNAs. Many miRNAs are reported to be differentially expressed in ADs and may play a pivotal role in regulating immune responses and autoimmunity. In this review, current research progress in the miRNAs in ADs was elucidated.

SUBMITTER: Qu Z 

PROVIDER: S-EPMC4065654 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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MicroRNAs in autoimmune diseases.

Qu Zigang Z   Li Wenhui W   Fu Baoquan B  

BioMed research international 20140604


Autoimmune diseases (ADs) are featured by body's immune responses being directed towards its own specific target organs or multiple organ systems, causing persistent inflammation and consequent tissue damage. miRNAs are small noncoding RNAs in a size of approximately 22 nt that play important regulatory roles in many organisms by cleavage or translational inhibition of targeted mRNAs. Many miRNAs are reported to be differentially expressed in ADs and may play a pivotal role in regulating immune  ...[more]

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