Ontology highlight
ABSTRACT:
SUBMITTER: Smith NL
PROVIDER: S-EPMC4065808 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Smith Norah L NL Wissink Erin E Wang Jocelyn J Pinello Jennifer F JF Davenport Miles P MP Grimson Andrew A Rudd Brian D BD
Journal of immunology (Baltimore, Md. : 1950) 20140521 1
Neonates often generate incomplete immunity against intracellular pathogens, although the mechanism of this defect is poorly understood. An important question is whether the impaired development of memory CD8+ T cells in neonates is due to an immature priming environment or lymphocyte-intrinsic defects. In this article, we show that neonatal and adult CD8+ T cells adopted different fates when responding to equal amounts of stimulation in the same host. Whereas adult CD8+ T cells differentiated i ...[more]