Ontology highlight
ABSTRACT:
SUBMITTER: McKay SL
PROVIDER: S-EPMC4065859 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
McKay Susannah L SL Johnson Tracy L TL
Molecular bioSystems 20100729 11
Pre-mRNA splicing, the removal of noncoding intron sequences from the pre-mRNA, is a critical reaction in eukaryotic gene expression. Pre-mRNA splicing is carried out by a remarkable macromolecular machine, the spliceosome, which undergoes dynamic rearrangements of its RNA and protein components to assemble its catalytic center. While significant progress has been made in describing the "moving parts" of this machine, the mechanisms by which spliceosomal proteins mediate the ordered rearrangemen ...[more]