Ontology highlight
ABSTRACT:
SUBMITTER: Whitworth DJ
PROVIDER: S-EPMC4066230 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Whitworth Deanne J DJ Ovchinnikov Dmitry A DA Sun Jane J Fortuna Patrick R J PR Wolvetang Ernst J EJ
Stem cells and development 20140401 13
In this study we have reprogrammed dermal fibroblasts from an adult female horse into equine induced pluripotent stem cells (equiPSCs). These equiPSCs are dependent only on leukemia inhibitory factor (LIF), placing them in striking contrast to previously derived equiPSCs that have been shown to be co-dependent on both LIF and basic fibroblast growth factor (bFGF). These equiPSCs have a normal karyotype and have been maintained beyond 60 passages. They possess alkaline phosphatase activity and ex ...[more]