Ontology highlight
ABSTRACT:
SUBMITTER: Klinman JP
PROVIDER: S-EPMC4066974 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Klinman Judith P JP Kohen Amnon A
Annual review of biochemistry 20130101
The relationship between protein dynamics and function is a subject of considerable contemporary interest. Although protein motions are frequently observed during ligand binding and release steps, the contribution of protein motions to the catalysis of bond making/breaking processes is more difficult to probe and verify. Here, we show how the quantum mechanical hydrogen tunneling associated with enzymatic C-H bond cleavage provides a unique window into the necessity of protein dynamics for achie ...[more]