Ontology highlight
ABSTRACT:
SUBMITTER: Lim AK
PROVIDER: S-EPMC4067262 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Lim Ai Khim AK Lorthongpanich Chanchao C Chew Ting Gang TG Tan Chin Wee Godwin CW Shue Yan Ting YT Balu Sathish S Gounko Natalia N Kuramochi-Miyagawa Satomi S Matzuk Martin M MM Chuma Shinichiro S Messerschmidt Daniel M DM Solter Davor D Knowles Barbara B BB
Development (Cambridge, England) 20130807 18
Mobilization of endogenous retrotransposons can destabilize the genome, an imminent danger during epigenetic reprogramming of cells in the germline. The P-element-induced wimpy testis (PIWI)-interacting RNA (piRNA) pathway is known to silence retrotransposons in the mouse testes. Several piRNA pathway components localize to the unique, germline structure known as the nuage. In this study, we surveyed mouse ovaries and found, for the first time, transient appearance of nuage-like structures in oo ...[more]