Ontology highlight
ABSTRACT:
SUBMITTER: Di Meglio P
PROVIDER: S-EPMC4067745 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Immunity 20140605 6
Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other autoimmune diseases, but the mechanisms are largely unknown. Here we show that the aryl hydrocarbon receptor (AhR), a transcription factor that senses environmental stimuli, modulates pathology in psoriasis. AhR-activating ligands reduced inflammation in the lesional skin of psoriasis patients, whereas AhR antagonists increased inflammation. Similarly, AhR signaling via the endogenous ligand FICZ reduced th ...[more]