Dataset Information

In utero exposure to alcohol and puberty in boys: a pregnancy cohort study.

ABSTRACT: Epidemiological studies have raised concerns about the reproductive consequences of in utero exposure to alcohol. Maternal lifestyle factors have been associated with altered pubertal development, but the impact of prenatal alcohol exposure on male puberty is unknown. Thus, the objective was to explore whether prenatal alcohol exposure alters pubertal development in boys.Follow-up of a Danish pregnancy cohort.Sons (N=2522) of women who were enrolled in a Danish pregnancy cohort between 1984 and 1987.Indicators of pubertal development, assessed by age at first nocturnal emission, voice break, acne and regular shaving.We found a tendency towards a later age at first nocturnal emission and voice break following in utero exposure to binge drinking. Boys exposed to ?5 binge drinking episodes during pregnancy experienced their first nocturnal emission 7.3?months (95% CI -2.8 to 17.4) later and voice break 4.9?months (95% CI -0.6 to 10.4) later than the unexposed boys. Results for average weekly alcohol consumption were in the same direction, but differences were smaller and not statistically significant.We found no strong support for the hypothesis that in utero exposure to weekly alcohol consumption is a risk factor for altered pubertal development, but a tendency towards delayed pubertal development among boys exposed to binge drinking during fetal life was observed. Longitudinal studies, with data collected as children go through puberty, are needed to explore this further.

SUBMITTER: Hakonsen LB

PROVIDER: S-EPMC4067820 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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In utero exposure to alcohol and puberty in boys: a pregnancy cohort study.

Håkonsen Linn Berger LB Brath-Lund Mette Louise ML Hounsgaard Marie Louise ML Olsen Jørn J Ernst Andreas A Thulstrup Ane Marie AM Bech Bodil Hammer BH Ramlau-Hansen Cecilia Høst CH

BMJ open 20140610 6

<h4>Objectives</h4>Epidemiological studies have raised concerns about the reproductive consequences of in utero exposure to alcohol. Maternal lifestyle factors have been associated with altered pubertal development, but the impact of prenatal alcohol exposure on male puberty is unknown. Thus, the objective was to explore whether prenatal alcohol exposure alters pubertal development in boys.<h4>Setting</h4>Follow-up of a Danish pregnancy cohort.<h4>Participants</h4>Sons (N=2522) of women who were ...[more]

PMID: 24916086

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Dataset Information

In utero exposure to alcohol and puberty in boys: a pregnancy cohort study.

Publications

In utero exposure to alcohol and puberty in boys: a pregnancy cohort study.

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