Ontology highlight
ABSTRACT:
SUBMITTER: Cecere G
PROVIDER: S-EPMC4068146 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Cecere Germano G Hoersch Sebastian S O'Keeffe Sean S Sachidanandam Ravi R Grishok Alla A
Nature structural & molecular biology 20140330 4
Argonaute proteins and their small RNA cofactors short interfering RNAs are known to inhibit gene expression at the transcriptional and post-transcriptional levels. In Caenorhabditis elegans, the Argonaute CSR-1 binds thousands of endogenous siRNAs (endo-siRNAs) that are antisense to germline transcripts. However, its role in gene expression regulation remains controversial. Here we used genome-wide profiling of nascent RNA transcripts and found that the CSR-1 RNA interference pathway promoted s ...[more]