Ontology highlight
ABSTRACT:
SUBMITTER: Kandler JL
PROVIDER: S-EPMC4068544 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Kandler Justin L JL Joseph Sandeep J SJ Balthazar Jacqueline T JT Dhulipala Vijaya V Read Timothy D TD Jerse Ann E AE Shafer William M WM
Antimicrobial agents and chemotherapy 20140512 7
Phosphoethanolamine (PEA) decoration of lipid A produced by Neisseria gonorrhoeae has been linked to bacterial resistance to cationic antimicrobial peptides/proteins (CAMPs) and in vivo fitness during experimental infection. We now report that the lptA gene, which encodes the PEA transferase responsible for this decoration, is in an operon and that high-frequency mutation in a polynucleotide repeat within lptA can influence gonococcal resistance to CAMPs. ...[more]