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Complete nucleotide sequence of two multidrug-resistant IncR plasmids from Klebsiella pneumoniae.

ABSTRACT: We report here the complete nucleotide sequence of two IncR replicons encoding multidrug resistance determinants, including ?-lactam (blaDHA-1, blaSHV-12), aminoglycoside (aphA1, strA, strB), and fluoroquinolone (qnrB4, aac6'-1b-cr) resistance genes. The plasmids have backbones that are similar to each other, including the replication and stability systems, and contain a wide variety of transposable elements carrying known antibiotic resistance genes. This study confirms the increasing clinical importance of IncR replicons as resistance gene carriers.

SUBMITTER: Compain F 

PROVIDER: S-EPMC4068571 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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Complete nucleotide sequence of two multidrug-resistant IncR plasmids from Klebsiella pneumoniae.

Compain Fabrice F   Frangeul Lionel L   Drieux Laurence L   Verdet Charlotte C   Brisse Sylvain S   Arlet Guillaume G   Decré Dominique D  

Antimicrobial agents and chemotherapy 20140421 7

We report here the complete nucleotide sequence of two IncR replicons encoding multidrug resistance determinants, including β-lactam (blaDHA-1, blaSHV-12), aminoglycoside (aphA1, strA, strB), and fluoroquinolone (qnrB4, aac6'-1b-cr) resistance genes. The plasmids have backbones that are similar to each other, including the replication and stability systems, and contain a wide variety of transposable elements carrying known antibiotic resistance genes. This study confirms the increasing clinical  ...[more]

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