Ontology highlight
ABSTRACT:
SUBMITTER: Balasubramanian V
PROVIDER: S-EPMC4068583 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20140512 7
AZD5847, a novel oxazolidinone with an MIC of 1 μg/ml, exhibits exposure-dependent killing kinetics against extracellular and intracellular Mycobacterium tuberculosis. Oral administration of AZD5847 to mice infected with M. tuberculosis H37Rv in a chronic-infection model resulted in a 1.0-log10 reduction in the lung CFU count after 4 weeks of treatment at a daily area under the concentration-time curve (AUC) of 105 to 158 μg · h/ml. The pharmacokinetic-pharmacodynamic parameter that best predict ...[more]