Ontology highlight
ABSTRACT:
SUBMITTER: Chew YL
PROVIDER: S-EPMC4068611 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Chew Yee Lian YL Fan Xiaochen X Götz Jürgen J Nicholas Hannah R HR
Journal of cell science 20130322 Pt 9
Protein with tau-like repeats (PTL-1) is the sole Caenorhabditis elegans homolog of tau and MAP2, which are members of the mammalian family of microtubule-associated proteins (MAPs). In mammalian neurons, tau and MAP2 are segregated, with tau being mainly localised to the axon and MAP2 mainly to the dendrite. In particular, tau plays a crucial role in pathology, as elevated levels lead to the formation of tau aggregates in many neurodegenerative conditions including Alzheimer's disease. We used ...[more]