Ontology highlight
ABSTRACT:
SUBMITTER: Gomez-Segui I
PROVIDER: S-EPMC4069034 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Gómez-Seguí Inés I Sánchez-Izquierdo Dolors D Barragán Eva E Such Esperanza E Luna Irene I López-Pavía María M Ibáñez Mariam M Villamón Eva E Alonso Carmen C Martín Iván I Llop Marta M Dolz Sandra S Fuster Oscar O Montesinos Pau P Cañigral Carolina C Boluda Blanca B Salazar Claudia C Cervera Jose J Sanz Miguel A MA
PloS one 20140624 6
Acute promyelocytic leukemia (APL) is characterized by the t(15;17)(q22;q21), but additional chromosomal abnormalities (ACA) and other rearrangements can contribute in the development of the whole leukemic phenotype. We hypothesized that some ACA not detected by conventional techniques may be informative of the onset of APL. We performed the high-resolution SNP array (SNP-A) 6.0 (Affymetrix) in 48 patients diagnosed with APL on matched diagnosis and remission sample. Forty-six abnormalities were ...[more]