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Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice.

ABSTRACT: Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

SUBMITTER: Rogers GB

PROVIDER: S-EPMC4069701 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice.

Rogers G B GB Kozlowska J J Keeble J J Metcalfe K K Fao M M Dowd S E SE Mason A J AJ McGuckin M A MA Bruce K D KD

Scientific reports 20140625

Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian mo ...[more]

PMID: 24961643

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