Selective autophagy of non-ubiquitylated targets in plants: looking for cognate receptor/adaptor proteins.

ABSTRACT: Cellular homeostasis is essential for the physiology of eukaryotic cells. Eukaryotic cells, including plant cells, utilize two main pathways to adjust the level of cytoplasmic components, namely the proteasomal and the lysosomal/vacuolar pathways. Macroautophagy is a lysosomal/vacuolar pathway which, until recently, was thought to be non-specific and a bulk degradation process. However, selective autophagy which can be activated in the cell under various physiological conditions, involves the specific degradation of defined macromolecules or organelles by a conserved molecular mechanism. For this process to be efficient, the mechanisms underlying the recognition and selection of the cargo to be engulfed by the double membrane autophagosome are critical, and not yet well understood. Ubiquit

SUBMITTER: Veljanovski V 

PROVIDER: S-EPMC4070572 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature