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Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors.

ABSTRACT: Choline kinase alpha is hyperactivated in many solid tumours and regulates malignant progression, making it a promising cancer drug target. The successful design and synthesis of novel inhibitors with high cellular activity are described.

SUBMITTER: Trousil S

PROVIDER: S-EPMC4071626 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Design of symmetrical and nonsymmetrical <i>N,N</i>-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors.

Trousil Sebastian S Carroll Laurence L Kalusa Andrew A Aberg Ola O Kaliszczak Maciej M Aboagye Eric O EO

MedChemComm 20130401 4

Choline kinase alpha is hyperactivated in many solid tumours and regulates malignant progression, making it a promising cancer drug target. The successful design and synthesis of novel inhibitors with high cellular activity are described. ...[more]

PMID: 24976941

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