Ontology highlight
ABSTRACT:
SUBMITTER: Hilbert BJ
PROVIDER: S-EPMC4072453 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Hilbert Brendan J BJ Grossman Steven R SR Schiffer Celia A CA Royer William E WE
FEBS letters 20140319 9
The oncogenic corepressors C-terminal Binding Protein (CtBP) 1 and 2 harbor regulatory d-isomer specific 2-hydroxyacid dehydrogenase (d2-HDH) domains. 4-Methylthio 2-oxobutyric acid (MTOB) exhibits substrate inhibition and can interfere with CtBP oncogenic activity in cell culture and mice. Crystal structures of human CtBP1 and CtBP2 in complex with MTOB and NAD(+) revealed two key features: a conserved tryptophan that likely contributes to substrate specificity and a hydrophilic cavity that lin ...[more]