Ontology highlight
ABSTRACT:
SUBMITTER: Yofe I
PROVIDER: S-EPMC4072511 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Yofe Ido I Zafrir Zohar Z Blau Rachel R Schuldiner Maya M Tuller Tamir T Shapiro Ehud E Ben-Yehezkel Tuval T
PLoS genetics 20140626 6
Introns are key regulators of eukaryotic gene expression and present a potentially powerful tool for the design of synthetic eukaryotic gene expression systems. However, intronic control over gene expression is governed by a multitude of complex, incompletely understood, regulatory mechanisms. Despite this lack of detailed mechanistic understanding, here we show how a relatively simple model enables accurate and predictable tuning of synthetic gene expression system in yeast using several predic ...[more]