Kinetochore genes are coordinately up-regulated in human tumors as part of a FoxM1-related cell division program.

ABSTRACT: The key player in directing proper chromosome segregation is the macromolecular kinetochore complex, which mediates DNA-microtubule interactions. Previous studies testing individual kinetochore genes documented examples of their overexpression in tumors relative to normal tissue, leading to proposals that up-regulation of specific kinetochore genes may promote tumor progression. However, kinetochore components do not function in isolation, and previous studies did not comprehensively compare the expression behavior of kinetochore components. Here we analyze the expression behavior of the full range of human kinetochore components in diverse published expression compendia, including normal tissues and tumor samples. Our results demonstrate that kinetochore genes are rarely overexpressed ind

SUBMITTER: Thiru P 

PROVIDER: S-EPMC4072572 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature