Ontology highlight
ABSTRACT:
SUBMITTER: Kabbout M
PROVIDER: S-EPMC4072627 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Kabbout Mohamed M Dakhlallah Duaa D Sharma Sudarshana S Bronisz Agnieszka A Srinivasan Ruchika R Piper Melissa M Marsh Clay B CB Ostrowski Michael C MC
PloS one 20140626 6
The ETS-family transcription factors Ets1 and Ets2 are evolutionarily conserved effectors of the RAS/ERK signaling pathway, but their function in Ras cellular transformation and biology remains unclear. Taking advantage of Ets1 and Ets2 mouse models to generate Ets1/Ets2 double knockout mouse embryonic fibroblasts, we demonstrate that deletion of both Ets1 and Ets2 was necessary to inhibit HrasG12V induced transformation both in vitro and in vivo. HrasG12V expression in mouse embryonic fibroblas ...[more]