Ontology highlight
ABSTRACT:
SUBMITTER: Labouebe G
PROVIDER: S-EPMC4072656 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Labouèbe Gwenaël G Liu Shuai S Dias Carine C Zou Haiyan H Wong Jovi C Y JC Karunakaran Subashini S Clee Susanne M SM Phillips Anthony G AG Boutrel Benjamin B Borgland Stephanie L SL
Nature neuroscience 20130127 3
The prevalence of obesity has markedly increased over the past few decades. Exploration of how hunger and satiety signals influence the reward system can help us understand non-homeostatic feeding. Insulin may act in the ventral tegmental area (VTA), a critical site for reward-seeking behavior, to suppress feeding. However, the neural mechanisms underlying insulin effects in the VTA remain unknown. We demonstrate that insulin, a circulating catabolic peptide that inhibits feeding, can induce lon ...[more]