Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.
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ABSTRACT:
SUBMITTER: Godinho-Silva C
PROVIDER: S-EPMC4072806 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.
Godinho-Silva Cristina C Marques Sofia S Fontinha Diana D Veiga-Fernandes Henrique H Stevenson Philip G PG Simas J Pedro JP
PLoS pathogens 20140626 6
Persistent infections are subject to constant surveillance by CD8+ cytotoxic T cells (CTL). Their control should therefore depend on MHC class I-restricted epitope presentation. Many epitopes are described for γ-herpesviruses and form a basis for prospective immunotherapies and vaccines. However the quantitative requirements of in vivo immune control for epitope presentation and recognition remain poorly defined. We used Murid Herpesvirus-4 (MuHV-4) to determine for a latently expressed viral ep ...[more]
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