Ontology highlight
ABSTRACT:
SUBMITTER: Jackson KJ
PROVIDER: S-EPMC4073884 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
The pharmacogenomics journal 20100601 4
The histidine triad nucleotide-binding protein-1 gene (HINT1) is implicated in schizophrenia and in the behavioral effects of morphine and amphetamine. Because nicotine dependence (ND) is highly comorbid with schizophrenia and other substance abuse, we examined the association of HINT1 with ND. Association analyses from two independent samples show that HINT1 gene variants are associated with ND phenotypes. Furthermore, human postmortem mRNA expression shows that smoking status and genotype infl ...[more]