Ontology highlight
ABSTRACT:
SUBMITTER: Cammas A
PROVIDER: S-EPMC4074165 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Cammas Anne A Sanchez Brenda Janice BJ Lian Xian Jin XJ Dormoy-Raclet Virginie V van der Giessen Kate K López de Silanes Isabel I Ma Jennifer J Wilusz Carol C Richardson John J Gorospe Myriam M Millevoi Stefania S Giovarelli Matteo M Gherzi Roberto R Di Marco Sergio S Gallouzi Imed-Eddine IE
Nature communications 20140627
HuR promotes myogenesis by stabilizing the MyoD, myogenin and p21 mRNAs during the fusion of muscle cells to form myotubes. Here we show that HuR, via a novel mRNA destabilizing activity, promotes the early steps of myogenesis by reducing the expression of the cell cycle promoter nucleophosmin (NPM). Depletion of HuR stabilizes the NPM mRNA, increases NPM protein levels and inhibits myogenesis, while its overexpression elicits the opposite effects. NPM mRNA destabilization involves the associati ...[more]