Ontology highlight
ABSTRACT:
SUBMITTER: Verhoff M
PROVIDER: S-EPMC4074212 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Verhoff Moritz M Seitz Stefanie S Paul Michael M Noha Stefan M SM Jauch Johann J Schuster Daniela D Werz Oliver O
Journal of natural products 20140520 6
The microsomal prostaglandin E2 synthase (mPGES)-1 is the terminal enzyme in the biosynthesis of prostaglandin (PG)E2 from cyclooxygenase (COX)-derived PGH2. We previously found that mPGES-1 is inhibited by boswellic acids (IC50 = 3-30 μM), which are bioactive triterpene acids present in the anti-inflammatory remedy frankincense. Here we show that besides boswellic acids, additional known triterpene acids (i.e., tircuallic, lupeolic, and roburic acids) isolated from frankincense suppress mPGES-1 ...[more]