Ontology highlight
ABSTRACT:
SUBMITTER: Walsh KM
PROVIDER: S-EPMC4074274 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Walsh Kyle M KM Codd Veryan V Smirnov Ivan V IV Rice Terri T Decker Paul A PA Hansen Helen M HM Kollmeyer Thomas T Kosel Matthew L ML Molinaro Annette M AM McCoy Lucie S LS Bracci Paige M PM Cabriga Belinda S BS Pekmezci Melike M Zheng Shichun S Wiemels Joseph L JL Pico Alexander R AR Tihan Tarik T Berger Mitchell S MS Chang Susan M SM Prados Michael D MD Lachance Daniel H DH O'Neill Brian Patrick BP Sicotte Hugues H Eckel-Passow Jeanette E JE van der Harst Pim P Wiencke John K JK Samani Nilesh J NJ Jenkins Robert B RB Wrensch Margaret R MR
Nature genetics 20140608 7
Glioma, the most common central nervous system cancer in adults, has poor prognosis. Here we identify a new SNP associated with glioma risk, rs1920116 (near TERC), that reached genome-wide significance (Pcombined = 8.3 × 10(-9)) in a meta-analysis of genome-wide association studies (GWAS) of high-grade glioma and replication data (1,644 cases and 7,736 controls). This region has previously been associated with mean leukocyte telomere length (LTL). We therefore examined the relationship between L ...[more]