Dataset Information

LEUNIG and SEUSS co-repressors regulate miR172 expression in Arabidopsis flowers.

ABSTRACT: Central to the ABCE model of flower development is the antagonistic interaction between class A and class C genes. The molecular mechanisms underlying the A-C antagonism are not completely understood. In Arabidopsis thaliana, miR172 is expressed in the inner floral whorls where it downregulates the class A gene APETALA 2 (AP2). However, what controls this predominantly inner whorl-specific expression of miR172 is not known. We show that the LEUNIG (LUG) and SEUSS (SEU) co-repressors repress miR172 expression in the outer whorls of A. thaliana flowers. The recruitment of LUG/SEU to the miR172 promoters is dependent on AP2, suggesting that AP2 represses the expression of its cognate microRNA. Our study provides new insights into the molecular mechanisms underlying the A-C antagonism and shed light on the transcriptional regulation of miR172 during flower development.

SUBMITTER: Grigorova B

PROVIDER: S-EPMC4074289 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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LEUNIG and SEUSS co-repressors regulate miR172 expression in Arabidopsis flowers.

Grigorova Boyana B Mara Chloe C Hollender Courtney C Sijacic Paja P Chen Xuemei X Liu Zhongchi Z

Development (Cambridge, England) 20110601 12

Central to the ABCE model of flower development is the antagonistic interaction between class A and class C genes. The molecular mechanisms underlying the A-C antagonism are not completely understood. In Arabidopsis thaliana, miR172 is expressed in the inner floral whorls where it downregulates the class A gene APETALA 2 (AP2). However, what controls this predominantly inner whorl-specific expression of miR172 is not known. We show that the LEUNIG (LUG) and SEUSS (SEU) co-repressors repress miR1 ...[more]

PMID: 21610026

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LEUNIG and SEUSS co-repressors regulate miR172 expression in Arabidopsis flowers.

Publications

LEUNIG and SEUSS co-repressors regulate miR172 expression in Arabidopsis flowers.

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