Ontology highlight
ABSTRACT:
SUBMITTER: Del Re DP
PROVIDER: S-EPMC4074544 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Del Re Dominic P DP Matsuda Takahisa T Zhai Peiyong P Maejima Yasuhiro Y Jain Mohit Raja MR Liu Tong T Li Hong H Hsu Chiao-Po CP Sadoshima Junichi J
Molecular cell 20140508 4
The Hippo pathway, evolutionarily conserved from flies to mammals, promotes cell death and inhibits cell proliferation to regulate organ size. The core component of this cascade, Mst1 in mammalian cells, is sufficient to promote apoptosis. However, the mechanisms underlying both its activation and its ability to elicit cell death remain largely undefined. We here identify a signaling cassette in cardiac myocytes consisting of K-Ras, the scaffold RASSF1A, and Mst1 that is localized to mitochondri ...[more]