Ontology highlight
ABSTRACT:
SUBMITTER: Scheinberg P
PROVIDER: S-EPMC4074770 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Scheinberg Phillip P Rios Olga O Scheinberg Priscila P Weinstein Barbara B Wu Colin O CO Young Neal S NS
American journal of hematology 20140601 6
In severe aplastic anemia, approximately one-third of responders to standard horse antithymocyte globulin (h-ATG) plus cyclosporine (CsA) will relapse. Anecdotal experience has suggested that a gradual CsA taper might avoid relapse, but this practice has not been rigorously assessed prospectively. In 2003, we adopted a strategy to taper CsA beyond 6 months, with the intention to reduce hematologic relapse compared with our extensive historical experience. In total, 102 patients received h-ATG/Cs ...[more]