Ontology highlight
ABSTRACT:
SUBMITTER: Mazzone JR
PROVIDER: S-EPMC4074917 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20140416 11
Several 2-carbon-linked trioxane dimer secondary alcohol carbonates 14 and thiocarbonates 15, combined with mefloquine and administered in a low single oral dose, prolonged the survival times of malaria-infected mice much more effectively than the popular monomeric antimalarial drug artemether plus mefloquine. Three dimer carbonates 14 and one dimer thiocarbonate 15 partially cured malaria-infected mice. ...[more]