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Antimalarial chemotherapy: artemisinin-derived dimer carbonates and thiocarbonates.

ABSTRACT: Several 2-carbon-linked trioxane dimer secondary alcohol carbonates 14 and thiocarbonates 15, combined with mefloquine and administered in a low single oral dose, prolonged the survival times of malaria-infected mice much more effectively than the popular monomeric antimalarial drug artemether plus mefloquine. Three dimer carbonates 14 and one dimer thiocarbonate 15 partially cured malaria-infected mice.

SUBMITTER: Mazzone JR

PROVIDER: S-EPMC4074917 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Antimalarial chemotherapy: artemisinin-derived dimer carbonates and thiocarbonates.

Mazzone Jennifer R JR Conyers Ryan C RC Tripathi Abhai K AK Sullivan David J DJ Posner Gary H GH

Bioorganic & medicinal chemistry letters 20140416 11

Several 2-carbon-linked trioxane dimer secondary alcohol carbonates 14 and thiocarbonates 15, combined with mefloquine and administered in a low single oral dose, prolonged the survival times of malaria-infected mice much more effectively than the popular monomeric antimalarial drug artemether plus mefloquine. Three dimer carbonates 14 and one dimer thiocarbonate 15 partially cured malaria-infected mice. ...[more]

PMID: 24775306

Similar Datasets

Antimalarial chemotherapy: orally curative artemisinin-derived trioxane dimer esters.

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Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs.

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The survival times of malaria-infected mice are prolonged more by several new two-carbon-linked artemisinin-derived dimer carbamates than by the trioxane antimalarial drug artemether.

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DNA binding by the antimalarial compound artemisinin.

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