Ontology highlight
ABSTRACT:
SUBMITTER: Martinez-Cerdeno V
PROVIDER: S-EPMC4075336 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Cell stem cell 20100301 3
We investigated a strategy to ameliorate the motor symptoms of rats that received 6-hydroxydopamine (6-OHDA) lesions, a rodent model of Parkinson's disease, through transplantation of embryonic medial ganglionic eminence (MGE) cells into the striatum. During brain development, embryonic MGE cells migrate into the striatum and neocortex where they mature into GABAergic interneurons and play a key role in establishing the balance between excitation and inhibition. Unlike most other embryonic neuro ...[more]