Dataset Information

Behcet's disease in HLA-B*51 negative Germans and Turks shows association with HLA-Bw4-80I.

ABSTRACT:

Introduction

Behçet's disease (BD) as systemic vasculitis of unknown etiology is associated with HLA-B*51 in European and Asian populations. HLA-A*26 was claimed as an additional BD susceptibility marker in Japanese and Greek patients. This study was performed to test for HLA associations in HLA-B*51 negative German and Turkish BD populations.

Methods

In total, 65 German and 46 Turkish patients lacking HLA-B*51 were analyzed in comparison to healthy HLA-B*51 negative Germans (n?=?1500) and Turks (n?=?130). HLA-A/B genotypes were determined by SSOP. P-values with correction for multiple testing (p(c)), ?2-test and odds ratio (OR) were used for statistical evaluation.

Results

HLA-A*26 was significantly more frequent in HLA-B*51- German patients [p(c)?=?0.0076, OR?=?3.23, 95% CI 1.63 to 6.39] than in respective controls. HLA-A*26 was also elevated in a smaller group of Turkish patients versus the controls. Significant association of HLA-Bw4 with isoleucine at amino-acid position 80 (HLA-Bw4-80I) was found in the HLA-B*51(-) German cohort of BD patients [p(c)?=?0.0042, OR?=?2.35, 95% CI 1.41 to 3.93) and in the Turkish patients in comparison to the respective controls [p?=?0.025, OR?=?2.17, 95% CI 1.09 to 4.31]. On the contrary, HLA-Bw4-80 T was reduced in both HLA-B*51(-) BD patient cohorts.

Conclusions

The study shows a significant association of HLA-Bw4-80I present on HLA-B*51 as well as on other B-locus molecules with BD. This indicates that distinctive Bw4 epitopes on HLA-B locus molecules could play a role in BD pathogenesis. The study also indicates an association with HLA-A*26 in German and Turkish BD patients as a genetic risk factor independent of HLA-B*51.

SUBMITTER: Kuranov AB

PROVIDER: S-EPMC4075409 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Behçet's disease in HLA-B*51 negative Germans and Turks shows association with HLA-Bw4-80I.

Kuranov Alexandr Borisovich AB Kötter Ina I Henes Jörg Christoph JC Abisheva Saule Tleubaevna ST Steiert Ingeborg I Riewerts Florian F Momynaliev Kuvat Temirgalievich KT Müller Claudia Anna CA

Arthritis research & therapy 20140526 3

<h4>Introduction</h4>Behçet's disease (BD) as systemic vasculitis of unknown etiology is associated with HLA-B*51 in European and Asian populations. HLA-A*26 was claimed as an additional BD susceptibility marker in Japanese and Greek patients. This study was performed to test for HLA associations in HLA-B*51 negative German and Turkish BD populations.<h4>Methods</h4>In total, 65 German and 46 Turkish patients lacking HLA-B*51 were analyzed in comparison to healthy HLA-B*51 negative Germans (n = ...[more]

PMID: 24887019

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