Ontology highlight
ABSTRACT:
SUBMITTER: Hochrath K
PROVIDER: S-EPMC4075965 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Hochrath Katrin K Ehnert Sabrina S Ackert-Bicknell Cheryl L CL Lau Yvonne Y Schmid Andrea A Krawczyk Marcin M Hengstler Jan G JG Dunn Jordanne J Hiththetiya Kanishka K Rathkolb Birgit B Micklich Kateryna K Hans Wolfgang W Fuchs Helmut H Gailus-Durner Valérie V Wolf Eckhard E de Angelis Martin Hrabě MH Dooley Steven S Paigen Beverly B Wildemann Britt B Lammert Frank F Nüssler Andreas K AK
Bone 20130329 2
Hepatic osteodystrophy (HOD) denotes the alterations in bone morphology and metabolism frequently observed in patients with chronic liver diseases, in particular in case of cholestatic conditions. The molecular mechanisms underlying HOD are only partially understood. In the present study, we characterized the bone phenotypes of the ATP-binding cassette transporter B4 knockout mouse (Abcb4(-/-)), a well-established mouse model of chronic cholestatic liver disease, with the aim of identifying and ...[more]