Ontology highlight
ABSTRACT:
SUBMITTER: Kim SS
PROVIDER: S-EPMC4076028 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Kim Sang-Soo SS Rait Antonina A Kim Eric E Pirollo Kathleen F KF Nishida Maki M Farkas Natalia N Dagata John A JA Chang Esther H EH
ACS nano 20140515 6
Temozolomide (TMZ)-resistance in glioblastoma multiforme (GBM) has been linked to upregulation of O(6)-methylguanine-DNA methyltransferase (MGMT). Wild-type (wt) p53 was previously shown to down-modulate MGMT. However, p53 therapy for GBM is limited by lack of efficient delivery across the blood brain barrier (BBB). We have developed a systemic nanodelivery platform (scL) for tumor-specific targeting (primary and metastatic), which is currently in multiple clinical trials. This self-assembling n ...[more]