Plasma HSPA12B is a potential predictor for poor outcome in severe sepsis.

ABSTRACT:

Introduction

Endothelium-derived molecules may be predictive to organ injury. Heat shock protein (HSP) A12B is mainly located in endothelial cells, which can be detected in the plasma of septic patients. Whether it is correlated with prognosis of sepsis remains unclear.

Methods

Extracellular HSPA12B (eHSPA12B) was determined in plasma of septic mice at 6 h, 12 h, 24 h and 48 h after cecal ligation and puncture (CLP). It was also detected in plasma of patients with severe sepsis, sepsis, systemic inflammatory response syndrome and healthy volunteers. The predictive value for prognosis of severe sepsis was assessed by receiver operating curve (ROC) and Cox regression analyses.

Results

eHSPA12B was elevated in plasma of CLP mice at 6 h and peaked at 24 h after surgery. A

SUBMITTER: Zhang R 

PROVIDER: S-EPMC4076283 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature