BRAF mutations in patients with non-small cell lung cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

BRAF mutations have been well described in non-small cell lung cancer (NSCLC) for several years, but the clinical features of patients harboring BRAF mutations are still not well described. We performed a meta-analysis to identify common clinical features in NSCLC patients carrying BRAF mutations.

Methods

We identified clinical studies that examined the association between BRAF mutations and features of NSCLC within PubMed, Embase and ISI Science Citation Index database up to October 2013. The effect size of clinical features was estimated by odds ratios (ORs) with 95% confidence interval (CI) for each study, using a fixed-effects or random-effects model.

Results

Ten studies with a total of 5599 NSCLC patients were included. There was a 3% (170/5599) BRAF m

SUBMITTER: Chen D 

PROVIDER: S-EPMC4076330 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature