Ontology highlight
ABSTRACT:
SUBMITTER: Ogawa K
PROVIDER: S-EPMC4076576 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Ogawa Kana K Tanaka Yoshihiko Y Uruno Takehito T Duan Xuefeng X Harada Yosuke Y Sanematsu Fumiyuki F Yamamura Kazuhiko K Terasawa Masao M Nishikimi Akihiko A Côté Jean-François JF Fukui Yoshinori Y
The Journal of experimental medicine 20140609 7
Mast cells play a key role in the induction of anaphylaxis, a life-threatening IgE-dependent allergic reaction, by secreting chemical mediators that are stored in secretory granules. Degranulation of mast cells is triggered by aggregation of the high-affinity IgE receptor, FcεRI, and involves dynamic rearrangement of microtubules. Although much is known about proximal signals downstream of FcεRI, the distal signaling events controlling microtubule dynamics remain elusive. Here we report that DOC ...[more]